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Retinal structural and vascular changes in posterior microphthalmos.

Ramesh Venkatesh1, Kushagra Jain1, Priya Srinivasan1

  • 1Department of Retina and Vitreous, Narayana Nethralaya, Bangalore, India.

Clinical & Experimental Optometry
|September 7, 2019
PubMed
Summary
This summary is machine-generated.

Posterior microphthalmos (PM) is a rare eye condition. This study reveals increased inner retinal thickness and higher foveal capillary vessel density in PM eyes, suggesting foreshortening causes these changes.

Keywords:
angiographymulticolouroptical coherence tomographypathogenesisposterior microphthalmos

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Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Medical Imaging

Background:

  • Posterior microphthalmos (PM) is a rare developmental disorder.
  • Characterized by high hyperopia, short axial length, and retinal papillomacular fold.
  • Anterior segment findings are typically normal.

Purpose of the Study:

  • To describe retinal structural and vascular changes in eyes with PM.
  • Utilized spectral domain optical coherence tomography, optical coherence tomography angiography, and multicolour imaging.
  • To understand the pathogenesis of posterior microphthalmos.

Main Methods:

  • Retrospective, comparative case series.
  • Included 10 eyes of 5 patients with PM and 10 age/sex-matched controls.
  • Assessed retinal thickness, multicolour imaging, and perifoveal vascular changes via OCT angiography.

Main Results:

  • Absence of foveal dip in all PM eyes (100%).
  • Elevated retinal papillomacular fold in 60% of PM eyes.
  • Increased inner retinal thickness and higher foveal capillary vessel density in PM eyes.

Conclusions:

  • Retinal foreshortening in one meridian may cause secondary changes in PM.
  • These changes include loss of foveal dip and retinal papillomacular fold formation.
  • Further validation in larger patient cohorts is needed.