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Related Experiment Videos

"Ia-like" antigens on human T cells.

M F Greaves, W Verbi, H Festenstein

    European Journal of Immunology
    |May 1, 1979
    PubMed
    Summary

    Human T cells express Ia-like and DRw alloantigens upon activation. This suggests either selection of a specific subset or derepression of DR locus genes during T cell activation, impacting immune responses.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Molecular Biology

    Background:

    • Human T lymphocytes are crucial for adaptive immunity.
    • Cell surface antigens play a role in immune cell recognition and function.
    • Ia-like and DRw alloantigens are important markers in immune responses.

    Purpose of the Study:

    • To investigate the expression of Ia-like heteroantigens and DRw alloantigens on human T lymphocytes.
    • To determine if T cell activation influences the expression of these antigens.
    • To elucidate the mechanism behind antigen expression on activated T cells.

    Main Methods:

    • Testing human T lymphocytes for cell surface Ia-like heteroantigen and DRw alloantigens.
    • Utilizing sheep (E) rosette assays and T antigen positivity.
    • Analyzing T cells negative for surface immunoglobulin (smIg-).
    • Activating T cells with allogeneic lymphocytes, sperm, or purified protein derivative (PPD).
    • Performing DRw typing on activated T cells.

    Main Results:

    • A small percentage (1-5%) of T cells (E+, T+, smIg-) were found to be Ia+.
    • Ia+ T cells were primarily restricted to the TG subset.
    • T cell activation significantly increased the proportion of Ia+ T cells.
    • DRw typing confirmed that Ia specificities on activated T cells were not passively acquired.

    Conclusions:

    • T cell activation leads to increased expression of Ia-like and DRw alloantigens.
    • This expression is likely due to either selection of a DRw+ T cell subset or derepression of DR locus genes.
    • Findings suggest a dynamic regulation of MHC class II-related molecules on T cells during activation.

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