Related Experiment Video
Updated: Jan 20, 2026
07:53
Analysis of Complex Molecules and Their Reactions on Surfaces by Means of Cluster-Induced Desorption/Ionization Mass Spectrometry
Published on: March 1, 2020
7.8K
Metoprolol-Induced Pemphigus-Like Reaction
Seena Patel1, Shanna Kim2, Carl Allen3,4
1Advanced Care Center and Special Needs Dentistry, Arizona School of Dentistry & Oral Health, A.T. Still University, Mesa, AZ.
Clinical Advances in Periodontics
|September 7, 2019
Summary
This case study identifies metoprolol as a potential cause of pemphigus vulgaris (PV), a rare autoimmune disease. Discontinuation of metoprolol led to complete resolution of PV-like symptoms, highlighting drug-induced autoimmune conditions.
Area of Science:
- Immunodermatology
- Autoimmune Blistering Diseases
- Pharmacovigilance
Background:
- Pemphigus vulgaris (PV) is a severe autoimmune disorder with often unknown triggers.
- Hypertension medications have been implicated in PV onset and exacerbation.
- Diagnosing drug-induced PV is difficult due to its similarity to idiopathic PV.
Observation:
- An elderly patient presented with unexplained gingival and cutaneous erosions.
- Extensive consultations failed to yield a diagnosis.
- Biopsy and medical history review implicated metoprolol.
Findings:
- Metoprolol was discontinued after consultation with the patient's cardiologist.
- The patient experienced complete resolution of all lesions following metoprolol cessation.
- This is the first reported case of metoprolol-induced PV in English literature.
Implications:
- Highlights the role of medications in immune-mediated diseases.
- Emphasizes the importance of considering drug-induced causes in PV diagnosis.
- Crucial for dental professionals managing patients with oral lesions potentially related to medications.
Related Concept Videos
02:06Allergic Reactions
32.1K
Overview
32.1K
03:06Reaction Mechanisms
30.5K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.5K
02:53Determining Order of Reaction
61.8K
Rate laws describe the relationship between the rate of a chemical reaction and the concentration of its reactants. In a rate law, the rate constant k and the reaction orders are determined experimentally by observing how the rate of reaction changes as the concentrations of the reactants are changed. A common experimental approach to the determination of rate laws is the method of initial rates. This method involves measuring reaction rates for multiple experimental trials carried out using...
61.8K
02:22Reaction Yield
59.3K
The theoretical yield of a reaction is the amount of product estimated to form based on the stoichiometry of the balanced chemical equation. The theoretical yield assumes the complete conversion of the limiting reactant into the desired product. The amount of product that is obtained by performing the reaction is called the actual yield, and it may be less than or (very rarely) equal to the theoretical yield.
59.3K
02:53Reaction Rate
62.3K
The rate of reaction is the change in the amount of a reactant or product per unit time. Reaction rates are therefore determined by measuring the time dependence of some property that can be related to reactant or product amounts. Rates of reactions that consume or produce gaseous substances, for example, are conveniently determined by measuring changes in volume or pressure.
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
62.3K
02:35Reaction Quotient
52.8K
The status of a reversible reaction is conveniently assessed by evaluating its reaction quotient (Q). For a reversible reaction described by m A + n B ⇌ x C + y D, the reaction quotient is derived directly from the stoichiometry of the balanced equation as
52.8K