Related Experiment Video
Updated: Jan 20, 2026
Isolation and Transplantation of Hematopoietic Stem Cells HSCs
Published on: February 25, 2007
Application of stem cell transplantation in autoimmune diseases
Sue-Ann Ng1, Keith M Sullivan2
1Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.
Purpose Of Review:
Autologous hematopoietic stem cell transplantation (HSCT) is a promising therapeutic modality for severe autoimmune diseases. In this review, we will outline the immunological mechanisms and the clinical evidence and experiences for therapeutic HSCT in autoimmune diseases, with particular focus on systemic sclerosis and multiple sclerosis.
Recent Findings:
Approximately 3000 patients with autoimmune diseases worldwide have been treated with HSCT. HSCT in systemic sclerosis has been shown in three randomized controlled trials to be associated with significant long-term event-free survival despite some transplant-related mortality in the first year. A recent controlled trial in multiple sclerosis has also show benefit with transplant.
Summary:
The aim of HSCT is to 'reset' one's immune system into a naïve and self-tolerant state through immune depletion and regulation. HSCT requires careful patient selection, close collaboration between physicians and expertise of transplant team to ensure optimal outcome.
Related Concept Videos
20:38Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
10:10Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
09:44Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:10Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
08:33Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus
08:53Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness