Relationship between Parameters Linked to Surgery, Hospitalization and Single Nucleotide Polymorphism in Patients...

Area of Science:

• Genetics and Molecular Biology
• Oncology
• Public Health

Background:

• Colorectal cancer (CRC) is a significant global health concern, particularly challenging to manage in elderly populations.
• Individualized treatment strategies are crucial for improving patient outcomes.
• Factors like comorbidities and disease stage influence hospitalization length and healthcare costs.

Purpose of the Study:

• To evaluate the association between the single nucleotide polymorphism (SNP) rs6983267 and the risk of developing colorectal cancer (CRC).
• To assess the impact of this specific genetic marker in a Romanian population.
• To explore potential correlations between genetic factors and clinical outcomes like length of hospitalization.

Main Methods:

• A case-control molecular genotyping study was conducted.
• DNA was extracted from peripheral venous blood of 32 CRC patients and 30 control individuals.
• Genotyping for the rs6983267 polymorphism was performed.

Main Results:

• The heterozygous genotype (G/T) for rs6983267 was found in 59.38% of CRC patients but in none of the control individuals.
• A higher percentage of CRC patients carried at least one G allele (81.21%) compared to controls (76.57%).
• An association was observed between length of hospitalization and factors influencing operating time.

Conclusions:

• The study suggests a potential, though not definitive, association between the rs6983267 SNP and CRC risk in the Romanian population.
• Further research is required to precisely determine the CRC risk associated with this SNP in this demographic.
• Clinical data indicated a link between hospitalization duration and surgical factors, independent of the studied SNP.