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Related Experiment Video

Updated: Jan 20, 2026

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Hydroxyapatite-alginate Based Matrices for Drug Delivery.

Amit K Nayak1, Md Saquib Hasnain2, Sitansu S Nanda3

  • 1Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, India.

Current Pharmaceutical Design
|September 7, 2019
PubMed
Summary
This summary is machine-generated.

Hydroxyapatite-alginate composites offer enhanced drug delivery by improving upon pure alginate matrices. These novel biomaterials provide sustained drug release, overcoming limitations like burst release and poor mechanical properties.

Keywords:
Hydroxyapatiteair-drying/spray dryingalginate based matricesbioinrganic-biopolymeric compositesbiopolymer(s)drug release.

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Last Updated: Jan 20, 2026

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Hydroxyapatite (HAp) is a biocompatible bioceramic extensively used in biomedical fields.
  • HAp is reinforced with biopolymers to enhance its applications, particularly in drug delivery.
  • HAp-alginate systems demonstrate stable integration of HAp crystallites within alginate molecules.

Purpose of the Study:

  • To comprehensively review the drug-releasing potential of HAp-alginate based matrices.
  • To discuss recent advancements in HAp-alginate composite development for drug delivery.
  • To highlight the benefits of HAp incorporation in alginate systems.

Main Methods:

  • HAp particles (synthesized or natural) are incorporated into alginate-based systems.
  • Common preparation involves ionic-gelation of sodium alginate.
  • Drying methods include air-drying or spray drying.

Main Results:

  • HAp-alginate systems effectively load various drug candidates.
  • These composites provide sustained drug delivery over extended periods.
  • They mitigate drawbacks of pure alginate, such as burst drug release and poor mechanical stability.

Conclusions:

  • HAp-alginate composites are effective for drug loading and sustained release.
  • These systems offer improved performance compared to pure alginate matrices.
  • Further research into HAp-alginate composites holds promise for advanced drug delivery solutions.