Related Experiment Video
Updated: Jan 20, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Application of Postlabeling Delay Time in 3-Dimensional Pseudocontinuous Arterial Spin-Labeled Perfusion Imaging in
Shilong Tang1, Xianfan Liu, Ling He
1From the Department of Radiology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Critical Disorders, Chongqing, China.
Insights
Optimal postlabeling delay (PLD) in 3D pseudocontinuous arterial spin-labeled (3D-pcASL) perfusion imaging varies by age in children. Infants under 6 months benefit from a 1025 ms PLD, while older children (6 months to 18 years) achieve best results with a 1525 ms PLD.
Area of Science:
- Medical Imaging
- Pediatric Radiology
- Neuroimaging
Background:
- 3D pseudocontinuous arterial spin-labeled (3D-pcASL) perfusion imaging is a valuable tool for assessing brain blood flow.
- Postlabeling delay (PLD) is a critical parameter influencing image quality and quantitative accuracy in ASL imaging.
- Determining optimal PLD values is essential for reliable perfusion measurements, especially in dynamic pediatric populations.
Purpose of the Study:
- To evaluate the application value of different postlabeling delay (PLD) values in 3D-pcASL perfusion imaging for normal children.
- To identify age-specific optimal PLD values to enhance image quality and quantitative accuracy in pediatric brain perfusion studies.
Main Methods:
- A cohort of 250 children (50 per age group: <1 month, 1-6 months, 6-12 months, 1-3 years, 3-6 years, 6-18 years) underwent 3D-pcASL MRI.
- Three PLD values (1025 ms, 1525 ms, 2025 ms) were applied.
- Image quality (Grade A-D), signal-to-noise ratio (SNR), and cerebral blood flow (CBF) were assessed and compared across PLD values and age groups.
Main Results:
- For infants <6 months, a PLD of 1025 ms yielded the highest image quality (Grade A in 43-46 cases) and superior SNR/CBF values.
- For children aged 6 months to 18 years, a PLD of 1525 ms resulted in the best image quality (Grade A in 43-46 cases) and higher SNR/CBF.
- Higher PLD values (1525 ms and 2025 ms) led to decreased SNR and CBF in younger infants, while 1025 ms was suboptimal for older children.
Conclusions:
- Optimal PLD values for 3D-pcASL perfusion imaging differ significantly across pediatric age groups.
- A PLD of 1025 ms is recommended for infants younger than 6 months.
- A PLD of 1525 ms is optimal for children aged 6 months to 18 years, ensuring reliable perfusion assessment.
Objective:
To explore the application value of postlabeling delay (PLD) in 3D pseudocontinuous arterial spin-labeled (3D-pcASL) perfusion imaging in normal children and to find the optimal PLD values for children at each age group.
Methods:
Five groups of children, with 50 patients in each group, who underwent routine magnetic resonance imaging scans with normal results were included. The patients were stratified according to the following ages: younger than 1 month, more than 1 month to 6 months, more than 6 months to 12 months, more than 1 year to 3 years, more than 3 years to 6 years, and more than 6 years to 18 years. All patients received 3D-pcASL perfusion magnetic resonance scanning. The PLD values were set to 1025, 1525, or 2025 milliseconds. In subjective evaluations, the signal-to-noise ratio (SNR) and cerebral blood flow (CBF) of 3D-pcASL perfusion images under different PLD values were compared and analyzed.
Results:
For patients in the <1-month group and >1-month to 6-month group, the images were mainly grade A when the PLD value was 1025 milliseconds, which equaled 43 and 46 cases, respectively. The brain CBF values and SNR values were higher than those of the images with PLD values of 1525 and 2025 milliseconds. For patients in the >6-month to 12-month group, >1-year to 3-year group, >3-year to 6-year group, and >6-year to 18-year group, the images were mainly grade A when the PLD value was 1525 milliseconds, which equaled 43, 45, 43, and 46 cases, respectively. The brain CBF values and SNR values were higher than those of the images with PLD values of 1025 and 2025 milliseconds.
Conclusions:
The optimal PLD values for 3D-pcASL perfusion imaging are different in children of different ages. The optimal PLD value for infants who are 6 months younger is 1025 milliseconds. The optimal PLD value for children older than 6 months to 18 years is 1525 milliseconds.
More Related Videos
05:23Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
Published on: May 31, 2024
11:45Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
Related Concept Videos
12:29Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
05:23Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
11:45Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
06:22Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts
07:36Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children
01:22Applications of Normal Distribution
The heights of 15 to 18-year-old males from Chile from 1984 to 1985 followed a normal distribution. The mean height is 172.36...