Related Experiment Video
Updated: Jan 20, 2026

Collection and Extraction of Occupational Air Samples for Analysis of Fungal DNA
Published on: May 2, 2018
Characterizing Long-Term Trajectories of Work and Disability Leave: The Role of Occupational Exposures, Health, and
Amal Harrati1, Peter Hepburn, Valerie Meausoone
1Stanford University School of Medicine, Palo Alto, California (Dr Harrati, Ms Meausoone, and Dr Cullen); Princeton University, Princeton, New Jersey (Dr Hepburn).
Objective:
This article characterizes trajectories of work and disability leave across the tenure of a cohort of 49,595 employees in a large American manufacturing firm.
Methods:
We employ sequence and cluster analysis to group workers who share similar trajectories of work and disability leave. We then use multinomial logistic regression models to describe the demographic, health, and job-specific correlates of these trajectories.
Results:
All workers were clustered into one of eight trajectories. Female workers (RR 1.3 to 2.1), those experiencing musculoskeletal disease (RR 1.3 to 1.5), and those whose jobs entailed exposure to high levels of air pollution (total particulate matter; RR 1.9 to 2.4) were more likely to experience at least one disability episode.
Conclusions:
These trajectories and their correlates provide insight into disability processes and their relationship to demographic characteristics, health, and working conditions of employees.
Related Concept Videos
12:02Collection and Extraction of Occupational Air Samples for Analysis of Fungal DNA
10:11Whole-Body Nanoparticle Aerosol Inhalation Exposures
15:00Setup of Consumer Wearable Devices for Exposure and Health Monitoring in Population Studies
10:22Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
07:08Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

