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Abnormalities in FGF family members and their roles in modulating depression-related molecules

Yu-Hao Xu1,2, Yan Zhu2,3, Yuan-Yuan Zhu1,2

  • 1Department of Neurology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.

The European Journal of Neuroscience
|September 7, 2019
PubMed

Insights

Fibroblast growth factors (FGFs) are increasingly linked to depression. Research shows FGF system changes are involved in depression and potentially other psychiatric disorders, requiring further study.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Molecular Biology

Background:

  • The fibroblast growth factor (FGF) system is gaining attention for its role in depression.
  • Understanding FGF's specific family members and modulated mechanisms is crucial.

Purpose of the Study:

  • To review the role of FGFs in depression.
  • To integrate clinical and basic research evidence on FGFs and depression.
  • To analyze FGF family member abnormalities and their modulation of depression-related molecules.

Main Methods:

  • Literature review integrating clinical and basic research findings.
  • Analysis of FGF family member abnormalities in depression.
  • Examination of FGFs' roles in modulating depression-related molecules.

Main Results:

  • Evidence suggests FGF system alterations are implicated in depression.
  • The FGF system may play a role in a broader spectrum of psychiatric disorders.
  • Specific FGF family members and their mechanisms in depression are identified.

Conclusions:

  • Changes in the fibroblast growth factor (FGF) system are involved in depression.
  • The FGF system's role may extend to other psychiatric disorders.
  • Further research is needed to fully elucidate the FGF family's role in depression and related conditions.
Keywords:
5-HTdepressionfibroblast growth factorglucocorticoid receptorinflammatory factorsneurotrophic factors

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