Related Experiment Video
Updated: Jan 20, 2026

A New Approach that Eliminates Handling for Studying Aggression and the "Loser" Effect in Drosophila melanogaster
Published on: December 30, 2015
Changing the Rules of the Game: How Winners Become Losers during Oncogenic Cell Selection
Cristina Villa Del Campo1, Miguel Torres1
1Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain.
Abstract:
As we age, our tissues become a mosaic of random mutations, many of which are oncogenic and promote the expansion of their carrier cells. In this issue of Cell Stem Cell, Fernandez-Antoran et al. (2019) show how commonly used medical procedures modify cell selection dynamics to either expand or eliminate cells carrying oncogenic p53 mutations.
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