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Human Pluripotent Stem Cell-Derived Cardiovascular Cells: From Developmental Biology to Therapeutic Applications

Stephanie I Protze1, Jee Hoon Lee2, Gordon M Keller3

  • 1McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Cell Stem Cell
|September 7, 2019
PubMed

Insights

Human pluripotent stem cells (hPSCs) are being directed to form heart cells, advancing cardiovascular research. This holds promise for disease modeling, drug screening, and regenerative therapies.

Area of Science:

  • Cardiovascular biology
  • Stem cell differentiation
  • Regenerative medicine

Background:

  • Understanding human heart development is key.
  • Human pluripotent stem cells (hPSCs) offer a powerful model system.
  • Directed differentiation protocols are advancing rapidly.

Purpose of the Study:

  • To review progress in generating cardiovascular cells from hPSCs.
  • To highlight applications of hPSC-derived cardiovascular cells.
  • To discuss the future potential of hPSCs in cardiac medicine.

Main Methods:

  • Leveraging knowledge of embryonic heart development.
  • Utilizing directed differentiation protocols for hPSCs.
  • Reviewing current literature and research trends.

Main Results:

  • hPSCs can be differentiated into major cardiac cell types.
  • Protocols for generating and maturing these cells are improving.
  • Significant progress has been made in the field.

Conclusions:

  • hPSC-derived cardiovascular cells are valuable tools.
  • Applications include disease modeling, drug screening, and cell therapy.
  • hPSCs show great promise for treating heart diseases.

Keywords:
atrial cardiomyocytescardiac conduction systemcardiac progenitorscardiovascular developmentcell therapydisease modelinghuman pluripotent stem cellsmodel of human developmentventricular cardiomyocytes

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