Domesticating the foreign body response: Recent advances and applications

Area of Science:

• Biomedical Engineering
• Immunology
• Materials Science

Background:

• The foreign body response (FBR) is an immune process that causes the rejection of implanted medical devices.
• This immune reaction challenges the performance, durability, and therapeutic effectiveness of implants.
• Overcoming FBR is crucial for advancing biomedical applications.

Purpose of the Study:

• To review the mechanistic understanding of the foreign body response.
• To highlight recent anti-FBR technologies developed in the last decade.
• To discuss the application of these technologies in biomedical fields.

Main Methods:

• Review of current literature on the foreign body response.
• Analysis of recent advancements in materials science and device design.
• Case studies of anti-FBR technologies in biomedical applications.

Main Results:

• Significant progress has been made in understanding the mechanisms of FBR.
• Novel anti-FBR technologies have shown success in preclinical and clinical settings.
• These technologies are applicable to implants, medical devices, and cell-based therapies.

Conclusions:

• Developed anti-FBR technologies offer promising strategies to mitigate immune rejection.
• Further innovation in this area can lead to new therapies and diagnostics.
• These advancements are poised to revolutionize patient care for intractable diseases.