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Related Experiment Video

Updated: Jan 19, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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Maternal Vertical Transmission Affecting Early-life Microbiota Development.

Shaopu Wang1, C Anthony Ryan2, Patrick Boyaval3

  • 1APC Microbiome Ireland, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland.

Trends in Microbiology
|September 8, 2019
PubMed
Summary

Early life interventions targeting the human microbiome offer significant health benefits. Understanding mother-to-infant microbial transmission is key to optimizing infant development and health outcomes.

Keywords:
infant microbiotamaternal microbiotavertical microbiota transmission

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Area of Science:

  • Microbiology
  • Human Development
  • Immunology

Background:

  • The human microbiome's link to health outcomes necessitates therapeutic manipulation strategies.
  • Early life presents a critical window for microbiome modulation due to its developmental plasticity.
  • Maternal microbiota transmission to infants influences early development and long-term health.

Purpose of the Study:

  • To review maternal microbiota adaptations during pregnancy, birth, and infancy.
  • To explore the acquisition and succession of the early-life microbiota.
  • To highlight research on mother-to-infant microbial transmission and its influencing factors.

Main Methods:

  • Literature review of studies on maternal and infant microbiomes.
  • Analysis of microbial adaptations across different life stages.
  • Synthesis of current knowledge on mother-to-infant transmission mechanisms.

Main Results:

  • Maternal microbiota undergoes significant adaptations throughout pregnancy and postpartum.
  • Early-life microbiota acquisition is influenced by birth mode and feeding practices.
  • Specific factors shape the dynamics of mother-to-infant microbial transmission.

Conclusions:

  • Mother-to-infant microbial transmission is a crucial determinant of infant microbiome development.
  • Targeting early-life microbial transmission holds therapeutic potential for health and development.
  • Further research is needed to fully elucidate and leverage these transmission pathways.