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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy06:51

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We describe an approach to reliably generate chimeric antigen receptor (CAR) T cells and test their differentiation and function in vitro and in...
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An Assay for Analyzing Test β-Glucan as an Immunotherapy Strategy against Brain Cancer Cells02:25

An Assay for Analyzing Test β-Glucan as an Immunotherapy Strategy against Brain Cancer Cells

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This video demonstrates an in vitro assay utilizing β-glucans to activate microglial cells for the production of superoxide radicals, a reactive oxygen species. In brain cancer cells, the generated reactive oxidants actively suppress tumor cell proliferation and induce cell...
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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

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The most commonly used method for generating large numbers of autologous dendritic cells (DCs) for use in tumor immunotherapy is described. The method uses IL-4 and GM-CSF to differentiate DCs from monocytes. The immature DCs are stimulated to mature and then loaded with antigens before they are injected back into the...
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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model08:06

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

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An experimental lung metastasis and CTL immunotherapy mouse model for analysis of tumor cells-T cell interaction in...
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Highly Stable, Functional Hairy Nanoparticles and Biopolymers from Wood Fibers: Towards Sustainable Nanotechnology11:32

Highly Stable, Functional Hairy Nanoparticles and Biopolymers from Wood Fibers: Towards Sustainable Nanotechnology

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Synthesis schemes to prepare highly stable wood fiber-based hairy nanoparticles and functional cellulose-based biopolymers have been detailed.
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Related Experiment Video

Updated: Jan 19, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

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Improving cancer immunotherapy through nanotechnology.

Michael S Goldberg1

  • 1STIMIT, Cambridge, MA, USA. michael@stimittx.com.

Nature Reviews. Cancer
|September 8, 2019
PubMed
Summary

Cancer immunotherapy shows promise, but limited patient response necessitates new strategies. Nanotechnology offers precise control over immune responses, enhancing cancer treatment effectiveness by targeting tumors more effectively.

Area of Science:

  • Oncology
  • Immunology
  • Nanotechnology
  • Bioengineering
  • Drug Delivery

Background:

  • Cancer immunotherapy, recognized by the 2018 Nobel Prize, harnesses the patient's immune system against tumors.
  • Current immunotherapies have modest response rates (~15%) due to tumor immune evasion mechanisms.
  • The spatiotemporal control of the immune system suggests therapies should also be spatiotemporally controlled for optimal therapeutic index.

Purpose of the Study:

  • To explore how nanotechnology and related approaches can enhance cancer immunotherapy.
  • To investigate methods for augmenting both endogenous and adoptively transferred immune cells.
  • To address limitations in current cancer immunotherapy through rational, deductive design.

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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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Related Experiment Videos

Last Updated: Jan 19, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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An Assay for Analyzing Test β-Glucan as an Immunotherapy Strategy against Brain Cancer Cells
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An Assay for Analyzing Test β-Glucan as an Immunotherapy Strategy against Brain Cancer Cells

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Main Methods:

  • Utilizing nanoparticles and biomaterials to program the location, pharmacokinetics, and co-delivery of immunomodulatory compounds.
  • Leveraging the convergence of nanotechnology, bioengineering, and drug delivery with cancer immunotherapy.
  • Informing specificity, influencing localization, and improving the function of immune cells.

Main Results:

  • Nanoparticles and biomaterials enable precise control over immunomodulatory compound delivery, surpassing traditional solution-based administration.
  • This approach allows for tailored immune responses that cannot be achieved with conventional methods.
  • The synergistic integration of multiple scientific fields facilitates addressing unmet needs in cancer treatment.

Conclusions:

  • Nanotechnology and related approaches offer a rational strategy to overcome tumor immune evasion and improve immunotherapy efficacy.
  • Precise spatiotemporal control via nanomaterials can significantly enhance the therapeutic index of immunomodulatory agents.
  • The convergence of advanced fields promises to significantly improve outcomes for patients undergoing cancer immunotherapy.