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Electrically conductive biomaterials based on natural polysaccharides: Challenges and applications in tissue
Somayeh Vandghanooni1, Morteza Eskandani1
1Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
International Journal of Biological Macromolecules
|September 9, 2019
Summary
This review explores using natural polysaccharides and conductive polymers to create advanced biomaterial scaffolds for tissue engineering (TE). These composite scaffolds enhance cell behavior and tissue regeneration, offering superior properties for TE applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Tissue engineering (TE) aims to repair or regenerate tissues/organs using cells, signal molecules, and scaffolds.
- Scaffolds, acting as artificial extracellular matrices (ECM), are crucial for cell attachment, differentiation, proliferation, and new tissue formation.
- Electric fields (EF) can influence cellular functions like polarity, wound healing, division, and differentiation.
Purpose of the Study:
- To review the fabrication and performance of composite biomaterial scaffolds.
- To investigate the synergistic use of natural polysaccharides and electrically conductive polymers in TE.
- To highlight the potential of these composite scaffolds in enhancing physicochemical and biological properties for tissue regeneration.
Main Methods:
- Review of literature on the combination of natural polysaccharides and electrically conductive polymers.
- Analysis of fabrication strategies for creating composite biomaterial scaffolds.
- Evaluation of scaffold performance in tissue engineering applications based on existing studies.
Main Results:
- Simultaneous use of natural polysaccharides and conductive polymers yields composite biomaterials with enhanced properties.
- These composite scaffolds demonstrate improved potential for cell attachment, differentiation, and proliferation.
- The integration of conductive polymers may enhance the effects of electric fields on cellular performance within scaffolds.
Conclusions:
- Combining natural polysaccharides with electrically conductive polymers offers a promising strategy for developing advanced TE scaffolds.
- These novel composite scaffolds exhibit superior characteristics for promoting tissue repair and regeneration.
- Further research into these materials could lead to significant advancements in the field of tissue engineering.
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