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Related Experiment Video

Updated: Jan 19, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
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Association between depression and disease-specific treatment.

Ga Bin Lee1, Hyeon Chang Kim2, Sun Jae Jung3

  • 1Department of Public Health, Yonsei University Graduate School, Seoul, Republic of Korea.

Journal of Affective Disorders
|September 9, 2019
PubMed
Summary

Depression increases overall medical service use, but individuals with major illnesses and depression seek less treatment. Careful consideration of mental health is crucial for effective healthcare utilization.

Keywords:
Charlson comorbidity indexDepressionMedical service utilizationMental healthprimary care

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Area of Science:

  • Health Services Research
  • Psychiatry
  • Public Health

Background:

  • Depression is a recognized factor influencing patient adherence to medical treatments.
  • The impact of comorbidities on the relationship between depression and treatment compliance requires further investigation.
  • Understanding depression's association with disease-specific treatment service utilization is essential for healthcare planning.

Purpose of the Study:

  • To explore the association between depression and disease-specific treatment service utilization.
  • To determine if comorbidities modify the relationship between depression and medical treatment compliance.

Main Methods:

  • A cross-sectional study analyzed data from 499,492 individuals with comorbidities from the Korean Community Health Survey (2009-2013).
  • Self-reported physician-diagnosed lifetime depression, current depressive symptoms, and medical service utilization were assessed.
  • Multiple logistic regression models investigated the association between depression status and overall treatment services, stratified by Charlson Comorbidity Index (CCI) defined conditions.

Main Results:

  • Individuals with a history of depression and current depressive symptoms demonstrated higher odds of using overall medical treatment services (men: OR=1.21; women: OR=1.13).
  • Conversely, depressed individuals with comorbidities defined by the CCI (e.g., diabetes, angina) showed lower utilization of treatment services compared to non-depressed individuals.
  • These findings highlight a complex interaction between depression, comorbidities, and healthcare seeking behavior.

Conclusions:

  • Depression is linked to increased overall medical service utilization, but this trend reverses for individuals with significant comorbidities.
  • Healthcare providers, particularly in primary care, must consider patients' mental health status to ensure appropriate and effective health service utilization.
  • Further research is needed to elucidate the causal pathways and develop targeted interventions.