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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Related Experiment Video

Updated: Jan 19, 2026

The Precision of Visual Working Memory with Delayed Estimation
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Statin-induced delayed rhabdomyolysis.

Umesh Sharma1

  • 1Hospital Internal Medicine, Mayo Clinic, Phoenix, Arizona, USA.

BMJ Case Reports
|September 9, 2019
PubMed
Summary
This summary is machine-generated.

Statin therapy can cause severe rhabdomyolysis, a serious muscle-damaging condition. Discontinuing statins led to rapid recovery in an elderly patient with severe muscle injury.

Keywords:
Drug InteractionsMusculoskeletal And Joint DisordersPain

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Area of Science:

  • * Clinical Medicine
  • * Pharmacology
  • * Toxicology

Background:

  • * Long-term statin use is common for hyperlipidemia management.
  • * Statins are associated with potential adverse effects, including myotoxicity.

Observation:

  • * An elderly woman on long-term statin therapy developed acute leg weakness, falls, and dark urine.
  • * Laboratory findings revealed significantly elevated muscle enzymes, indicative of rhabdomyolysis.
  • * Autoimmune myositis was ruled out through comprehensive workup.

Findings:

  • * Discontinuation of statin medication resulted in rapid clinical improvement and normalization of muscle enzyme levels within two weeks.
  • * The patient's creatinine phosphokinase (CPK) levels returned to baseline (51 U/L) from a peak of 12,896 U/L.

Implications:

  • * This case highlights the potential for statins to induce severe rhabdomyolysis, even after prolonged use.
  • * Clinicians should maintain a high index of suspicion for drug-induced myopathy in patients presenting with unexplained muscle symptoms.
  • * Prompt recognition and withdrawal of the offending agent are crucial for favorable outcomes in statin-induced rhabdomyolysis.