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Updated: Jan 19, 2026

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application
Published on: July 9, 2020
Is There a Safety Concern for Drug-Coated Balloons in Peripheral Arterial Disease?
Mohamed M Gad1,2, Antonette K Karrthik1, Ahmad A Mahmoud3
1Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Heart and Vascular Institute, Cleveland, OH, USA.
Purpose Of Review:
Drug-coated balloons (DEB) and drug-eluting stents (DES) emerged as a tool to aid in lowering the rates of neointimal hyperplasia and target lesion restenosis following endovascular peripheral arterial disease (PAD) interventions.
Recent Findings:
Although the initial trials comparing these devices with non-drug balloons and stents showed favorable results, more recent data raised concerns regarding the mid to long-term safety of these devices. In this review, we will discuss the evolution of endovascular therapy for PAD, with highlights regarding the recent debates on the long-term safety of the drug-coated devices for treatment of PAD.
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Peripheral Artery Disease I: Introduction
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