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Updated: Jan 19, 2026
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Drug Classes and Categories
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Emerging Drug Classes and Their Potential Use in Hypertension
Michel Azizi1,2,3, Patrick Rossignol4, Jean-Sébastien Hulot1,3,5
1From the Université de Paris, CIC1418, INSERM, F-75015 Paris, France (M.A., J.-S.H.).
Hypertension (Dallas, Tex. : 1979)
|September 10, 2019
Summary
New antihypertensive drugs are essential for better blood pressure control, addressing treatment gaps and cardiovascular risks. Emerging drug classes show promise, though development faces hurdles.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Drug Development
Background:
- Hypertension prevalence is rising globally due to aging and obesity.
- Current antihypertensive treatments have limitations, including nonadherence and counter-regulatory effects.
- Need exists for novel antihypertensive agents targeting new pathways to improve control and reduce cardiovascular risk.
Purpose of the Study:
- To review emergent drug classes for hypertension treatment.
- To discuss challenges in developing new antihypertensive medications.
- To highlight novel therapeutic targets and agents.
Main Methods:
- Literature review of recent developments in antihypertensive drug discovery.
- Analysis of emerging drug classes and their mechanisms of action.
- Discussion of challenges in clinical development and market access.
Main Results:
- Several novel drug classes are under development, including dual angiotensin II receptor-neprilysin inhibitors, soluble guanylate cyclase stimulators, mineralocorticoid receptor antagonists, and sodium-glucose cotransporter 2 inhibitors.
- Some agents are developed for co-existing conditions like heart failure and diabetic kidney disease.
- Aminopeptidase A inhibitors and endothelin receptor antagonists are specifically targeted for hypertension.
Conclusions:
- Despite development challenges, new antihypertensive drug classes are crucial for improving patient outcomes.
- Novel agents offer potential to overcome limitations of existing therapies.
- Continued research and development are vital for addressing the unmet needs in hypertension management.
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