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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Accessing the Cytotoxicity and Cell Response to Biomaterials09:46

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This methodology aims to evaluate biomaterial cytotoxicity through the preparation of soluble extracts, using viability assays and phenotypic analysis, including flow cytometry, RT-PCR, immunocytochemistry, and other cellular and molecular biology...
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Overview of Biomaterials07:44

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Biomaterials are materials engineered to interact favorably with biological organisms or molecules. These materials can be derived from or produced by an organism, or can even be a synthesized polymer. Engineers use these novel materials in a wide range of applications, such as tissue engineering, biosensing and drug delivery.
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Electrospinning of Silk Biomaterials07:58

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Silk fibers have been processed and used to create fabrics and threads for centuries. However, the solubilizing of silk fibers, thereby turning it into a versatile pre-polymer solution is a much newer technology. Solubilized silk can be processed in many different ways to create a biocompatible material with controllable mechanical properties.
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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We describe here a protocol for microinjection in the rodent brain that uses quartz needles. These needles do not produce detectable tissue damage and ensure reliable delivery even in deep regions. Moreover, they can be adapted to research needs by personalized designs and can be...
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Updated: Jan 19, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials
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Biomaterials for Personalized Cell Therapy.

Amanda L Facklam1,2, Lisa R Volpatti1,3, Daniel G Anderson1,3,4,5

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Advanced Materials (Deerfield Beach, Fla.)
|September 10, 2019
PubMed
Summary
This summary is machine-generated.

Biomaterials enhance cell therapies for tissue regeneration, diabetes, and cancer. Engineering these materials enables personalized treatments tailored to individual patient needs.

Keywords:
biomaterialscell therapydrug deliveryimmunotherapypersonalized medicineregenerative medicine

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Immunotherapy

Background:

  • Cell therapy offers novel treatments for diseases like diabetes and cancer.
  • Biomaterials can support cell viability, function, and 3D organization in therapeutic applications.
  • Personalized medicine increasingly utilizes patient-specific cells and tailored biomaterials.

Purpose of the Study:

  • To review the role of biomaterials in advancing cell therapies.
  • To highlight the engineering of material properties for personalized cell therapies.
  • To focus on applications in tissue regeneration, protein delivery, and cancer immunotherapy.

Main Methods:

  • Review of current literature on biomaterials in cell therapy.
  • Analysis of engineered material properties and functionalities.
  • Examination of personalized approaches in cell-based treatments.

Main Results:

  • Biomaterials significantly improve cell therapy outcomes.
  • Engineered biomaterials enable precise control over cellular behavior.
  • Personalized cell therapies show promise for treating complex diseases.

Conclusions:

  • Biomaterials are crucial for the next generation of personalized cell therapies.
  • Advanced material design will drive innovation in regenerative medicine and immunotherapy.
  • Tailoring biomaterials to individual patients enhances therapeutic efficacy.