Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Application of Microwave Ablation in Laparoscopic Partial Splenectomy03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

483
The use of laparoscopic partial splenectomy has been limited due to the high risk of bleeding during surgery. Therefore, we introduce a laparoscopic method combined with microwave ablation to solve the problem of intraoperative...
483
Robot-assisted Partial Splenectomy08:34

Robot-assisted Partial Splenectomy

362
This protocol describes a robot-assisted partial splenectomy for a benign splenic tumor. The robotic approach optimizes spleen preservation by enhancing surgical precision, minimizing blood loss, and improving postoperative outcomes. Key surgical steps include meticulous splenic hilum dissection, selective vascular ligation, intraoperative ultrasonography, and controlled parenchymal...
362
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.5K
3.5K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.3K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.3K
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

702
With the rapid advancement of laparoscopic techniques, the minimally invasive benefits of laparoscopic splenectomy combined with pericardial devascularization have become increasingly evident. In this context, we present a protocol for performing laparoscopic splenectomy alongside pericardial devascularization to treat hypersplenism and esophageal variceal hemorrhage resulting from portal...
702

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SOPA and SIMPA: normalized single-sample integrated multiomics pathway analysis of tumor heterogeneity in solid cancers.

Briefings in bioinformatics·2026
Same author

Postoperative quality of life and nutritional outcomes following subtotal, proximal, or distal gastrectomy for upper gastric cancer: a retrospective cohort study.

Surgery today·2026
Same author

Mechanisms of chemoresistance in gastric cancer: interplay between microRNAs and the tumor microenvironment.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2026
Same author

Artificial intelligence-based reclassification of gastric adenocarcinoma enables prognostic stratification via diffuse-type patch proportion.

International journal of medical informatics·2026
Same author

Remnant Gastric Necrosis after Laparoscopic Distal Gastrectomy Managed with Double-Elemental Diet Tube and Laparoscopic Gastrojejunostomy: A Case Report.

Surgical case reports·2026
Same author

Impact of concomitant cholecystectomy during gastrectomy for gastric cancer on the postoperative quality of life.

Surgery today·2026

Related Experiment Video

Updated: Jan 19, 2026

Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

483

The non-coding RNome after splenectomy.

Mihnea P Dragomir1,2, Stefan Tudor2, Keishi Okubo1

  • 1Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Journal of Cellular and Molecular Medicine
|September 10, 2019
PubMed
Summary
This summary is machine-generated.

Splenectomy alters circulating non-coding RNAs (ncRNAs), including microRNAs (miRNAs), potentially explaining post-surgical complications. These ncRNAs show cell-specific expression and regulate immune pathways.

Keywords:
OPSImicroRNAnon-coding RNApyknonsepsissplenectomy

More Related Videos

Robot-assisted Partial Splenectomy
08:34

Robot-assisted Partial Splenectomy

Published on: January 2, 2026

362
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

702

Related Experiment Videos

Last Updated: Jan 19, 2026

Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

483
Robot-assisted Partial Splenectomy
08:34

Robot-assisted Partial Splenectomy

Published on: January 2, 2026

362
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

702

Area of Science:

  • Immunology
  • Molecular Biology
  • Genomics

Background:

  • Splenectomy is a common procedure with known infectious and non-infectious complications.
  • The underlying mechanisms of these complications, particularly involving non-coding RNAs, remain largely unknown.

Purpose of the Study:

  • To investigate the role of circulating non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), in post-splenectomy complications.
  • To analyze the global ncRNA profile in leukocytes following splenectomy.

Main Methods:

  • Analysis of circulating plasma miRNAs in splenectomized patients.
  • Genome-wide profiling of non-coding RNAs (ncRNAs) in peripheral blood leukocytes.
  • Pathway analysis of deregulated ncRNAs.
  • Cell-specific expression analysis of ncRNAs in 15 immune cell types.

Main Results:

  • Specific miRNAs (miR-223, miR-146a, miR-16, miR-93, miR-26a, miR-26b) showed altered expression post-splenectomy, with some patterns resembling sepsis.
  • Splenectomy induced a reorganization of the leukocyte ncRNome, with increased miRNAs and decreased transcribed pyknons (T-PYKs).
  • Deregulated miRNAs target pathways crucial for immunity, cancer, and endothelial growth.
  • Plasma and cellular ncRNAs exhibit cell-specific expression patterns within immune cells.

Conclusions:

  • Circulating ncRNAs, particularly miRNAs, are dysregulated after splenectomy.
  • These ncRNAs may play a role in the immune alterations and complications following splenectomy.
  • The findings highlight the potential of ncRNAs as biomarkers or therapeutic targets in post-splenectomy care.