How are Humans Exposed to Organic Chemicals Released to Indoor Air?

Humans are exposed to organic chemicals released to indoor air through near-field exposure routes such as air inhalation and nondietary dust ingestion as well as far-field exposure routes such as consumption of food. Here, we explore the relative importance of near- and far-field exposure routes and its variability between chemicals, age groups, and subpopulations, by modeling aggregate human exposure to indoor-released chemicals with diverse partitioning behavior and degradability. Our model results indicate that if chemicals are assumed to be perfectly persistent, dietary and nondietary ingestion dominates human exposure to hydrophobic chemicals of relatively low volatility (with an octanol-air partition coefficient K_OA > 10^6.5 and an octanol-water partition coefficient K_OW < 10¹¹), whereas inhalation of indoor air dominates human exposure to volatile chemicals. Other exposure routes, for example, dermal absorption and drinking water, make a relatively small contribution to human exposure. Reduced chemical persistence in environmental media and biota lowers the contribution of dietary ingestion. For most chemicals other than those with a K_OA between 10⁹ and 10¹² and a K_OW between 10⁶ and 10⁹ (e.g., polybrominated diphenyl ethers), the relative importance of near- and far-field exposure routes is primarily governed by chemical partitioning and degradability rather than age- and population-dependent human exposure factors.