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Updated: Jan 19, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Fisetin, a potential caloric restriction mimetic, modulates ionic homeostasis in senescence induced and naturally
Sandeep Singh1, Geetika Garg1, Abhishek Kumar Singh1,2
1Department of Biochemistry, University of Allahabad, Allahabad, India.
Context:
Fisetin as a caloric restriction mimetic (CRM) exerts numerous beneficial effects on different aging model systems. The effect of fisetin on erythrocyte membrane functions against induced aging is not very clear.
Objectives:
The potential role of fisetin in the modulation of erythrocytes membrane-bound transporters during natural and induced aging in rats was assessed.
Materials And Methods:
Male Wistar rats were used for natural and D-galactose (D-gal) induced aging model. After supplementation with fisetin, the activities of different membrane transporters and biomarkers of oxidative stress were evaluated.
Results:
Fisetin modulated membrane transporters such as calcium-ATPase, sodium potassium-ATPase and sodium hydrogen exchanger during senescence-induced as well as in natural aging. Fisetin also protected oxidative modifications in rat aging.
Discussion And Conclusion:
Fisetin supplementation improves the ionic homeostasis, a factor that is involved in the aetiology of several age-associated diseases, in naturally old as well as D-gal induced aged rats.
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