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Periostin concentration in exhaled breath condensate in children with mild asthma

Patrycja Nejman-Gryz1, Katarzyna Górska1, Katarzyna Krenke2

  • 1Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|September 10, 2019
PubMed

Insights

Exhaled breath condensate (EBC) periostin levels were measured in children with mild asthma. The study found no significant difference in EBC periostin between asthmatic children and controls, suggesting it may not be a useful asthma biomarker.

Area of Science:

  • Pulmonary Medicine
  • Biomarker Discovery
  • Pediatric Asthma Research

Background:

  • Periostin is a known marker for eosinophilic inflammation in asthma.
  • Limited data exists on periostin levels in exhaled breath condensate (EBC) in pediatric asthma patients.

Purpose of the Study:

  • To investigate EBC periostin concentration in children with mild asthma.
  • To assess the utility of EBC periostin as a potential biomarker for pediatric asthma.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure EBC and serum periostin.
  • Study included 23 children with asthma and 23 healthy controls.

Main Results:

  • EBC periostin concentrations were significantly lower than serum levels (250-780 fold).
  • No significant differences in EBC or serum periostin were found between asthmatic children and controls.
  • Serum periostin showed an inverse correlation with BMI and age in both groups.

Conclusions:

  • Periostin can be measured in both serum and EBC in children with mild asthma.
  • Low periostin levels and lack of difference between groups suggest EBC periostin is not a useful asthma biomarker in this pediatric population.
Abstract

Keywords:
Childhood asthmaEBCperiostinserum

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