Application of simplex lattice design for the development of extended release tablets of model drug diclofenac sodium
Related Experiment Video
Updated: Jan 19, 2026

Extending the Lifespan of Soluble Lead Flow Batteries with a Sodium Acetate Additive
Published on: January 7, 2019
Shivaji Phadke1, Tanvi Kanekar1, Suhas Gumaste1
1Genus Lifesciences Inc., 700N Fenwick Street, Allentown, PA 18109, USA.
Abstract:
Aim: Simplex lattice design was applied to predict extent of drug release from extended release diclofenac sodium tablets. Methods: The effects of composition on dissolution rate were evaluated by varying the levels of hydroxypropyl methylcellulose, dicalcium phosphate and cornstarch via three component design. Results: The rate of drug release was primarily dictated by the proportion of hydroxypropyl methylcellulose and was also affected by the proportion of dicalcium phosphate and the method of processing (direct compression/wet granulation). Polynomial equations constructed for directly compressed and wet-granulated formulations could successfully predict the extent of drug release at an arbitrary time point of 3 h. Conclusion: Simplex lattice design is a viable tool to predict the drug release patterns of extended release formulations.
More Related Videos
07:23Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
Published on: October 20, 2023
10:33Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
Published on: October 26, 2015
Related Concept Videos
08:35Extending the Lifespan of Soluble Lead Flow Batteries with a Sodium Acetate Additive
07:23An All-Human Hepatic Culture System for Drug Development Applications
In Vitro Drug Release Testing: Overview, Development and Validation
10:33Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
Lattice Centering and Coordination Number
Types of Unit Cells
Imagine taking a large number of identical...
05:44Formation of Dispersible Taohong Siwu Tablets