Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

1.5K
This article presents a protocol for executing the highly translational and independently proven mouse Stroke Unit (mSU) concept in large-stroke mice. It also provides a standardized protocol for executing the focal experimental stroke scale in mice, which evaluates stroke focal deficits detected even long-term.
1.5K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

7.9K
This methodology produces decision trees that target population groups more prone to suffering from mild cognitive impairment and are useful for cost-effective selective screening of the...
7.9K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

911
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
911
Study Design in Statistics01:15

Study Design in Statistics

9.9K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
9.9K
An Improved Method for Rapid Intubation of the Trachea in Mice08:46

An Improved Method for Rapid Intubation of the Trachea in Mice

26.3K
This article presents a rapid and simple method for administering bleomycin directly into the mouse trachea via intubation. Key advantages of this method are that it is highly reproducible, easy to master, and does not require specialized equipment or lengthy recovery...
26.3K
Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke06:36

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

8.8K
Here we present a protocol to quantify brain injury, locomotor deficits and neuroinflammation following bleeding in the brain in zebrafish larvae, in the context of human intracerebral hemorrhage (ICH).
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting 30-Day Readmission After Stroke: A Systematic Review and Meta-Analysis to Inform Predictor Selection.

Diagnostics (Basel, Switzerland)·2026
Same author

Synthesizing Explainability Across Multiple ML Models for Structured Data.

Algorithms·2026
Same author

Enhancing Thrombolysis Times in Acute Ischemic Stroke With Regional Dashboards: Results From the Florida Stroke Registry.

Journal of the American Heart Association·2025
Same author

Patterns and Outcomes of Endovascular Thrombectomy Among Patients Over Age 80 Years: The Florida Stroke Registry.

Journal of the American Heart Association·2025
Same author

Association of ICH Score with Withdrawal of Life-Sustaining Treatment: A Decade from the Florida Stroke Registry.

medRxiv : the preprint server for health sciences·2025
Same author

Race and ethnic disparities in rehabilitation services and functional recovery post-stroke.

medRxiv : the preprint server for health sciences·2025

Related Experiment Video

Updated: Jan 19, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.5K

The Mild and Rapidly Improving Stroke Study (MaRISS): Rationale and design.

Jose G Romano1, Hannah Gardener1, Iszet Campo-Bustillo1

  • 1Miller School of Medicine, University of Miami, Miami, FL, USA.

International Journal of Stroke : Official Journal of the International Stroke Society
|September 10, 2019
PubMed
Summary

Mild stroke patients often experience disability, yet remain understudied. This research clarifies their outcomes and the impact of alteplase treatment, aiding clinical management.

Keywords:
Strokeoutcome assessmentresearch designtissue plasminogen activator

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K
An Improved Method for Rapid Intubation of the Trachea in Mice
08:46

An Improved Method for Rapid Intubation of the Trachea in Mice

Published on: February 22, 2016

26.3K

Related Experiment Videos

Last Updated: Jan 19, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.5K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K
An Improved Method for Rapid Intubation of the Trachea in Mice
08:46

An Improved Method for Rapid Intubation of the Trachea in Mice

Published on: February 22, 2016

26.3K

Area of Science:

  • Neurology
  • Stroke Medicine
  • Clinical Trials

Background:

  • Mild and rapidly improving stroke symptoms are common but understudied in acute stroke research.
  • Previous studies indicate a significant proportion of these patients experience residual disability.

Purpose of the Study:

  • To determine long-term outcomes for patients with mild or rapidly improving ischemic stroke.
  • To identify predictors of outcome in this patient group.
  • To evaluate the association between alteplase treatment and patient outcomes.

Main Methods:

  • Prospective observational study design.
  • Inclusion of patients with mild ischemic stroke (NIHSS ≤ 5) or rapidly improving symptoms within 4.5 hours of onset.
  • Revised sample size of 2000 participants based on treatment rates.

Main Results:

  • Primary outcome: proportion of patients with modified Rankin Scale (mRS) ≥ 2 at 90 days.
  • Primary safety outcome: symptomatic hemorrhagic transformation within 36 hours for alteplase-treated patients.
  • Secondary outcomes include functional status (Barthel Index, Stroke Impact Scale), quality of life, and mortality.

Conclusions:

  • The MaRISS study aims to define outcomes and predictors in mild/improving stroke.
  • It will clarify alteplase's effects in this specific population.
  • Findings will inform clinical management strategies for mild stroke patients.