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Updated: Jan 19, 2026
Targeted Cancer Therapies: Imatinib Mesylate and Trastuzumab
Sorcin: a novel potential target in therapies of cancers
Xinyi Zhou1, Xue Wu2, Baoan Chen2
1Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, People's Republic of China.
Abstract:
Soluble resistance-related calcium-binding protein (sorcin) is a member of the penta-EF-hand protein family. Sorcin is widely distributed in normal human tissues, such as the brain, heart, lymphocytes, kidneys, breast and skin. Findings suggest that sorcin is associated with the regulation of calcium homeostasis, cell cycle and vesicle trafficking. It has been reported that many types of non-neoplastic diseases such as diabetes, viral infection, infertility, and nervous system diseases were affected by the expression of sorcin. One of the main issues is the role of sorcin in neoplastic diseases. Research proved that sorcin can be found to overexpress in cells of several cancers, particularly in the case of multidrug-resistant cancers. Additionally, the researchers proposed that the expression of sorcin was significantly associated with the foundation of multidrug resistance (MDR). All the findings mentioned above emphasized the importance of studying sorcin. This review mainly includes the following aspects: functions of sorcin, role in non-neoplastic and neoplastic diseases, and research related to drugs. To sum up, sorcin is a potential novel target to be studied to deal with MDR.
Insights
Soluble resistance-related calcium-binding protein (sorcin) is linked to cell functions and various diseases. Overexpression of sorcin is associated with multidrug resistance (MDR) in cancer, suggesting it as a potential therapeutic target.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Soluble resistance-related calcium-binding protein (sorcin) is a penta-EF-hand protein found in human tissues.
- Sorcin plays roles in calcium homeostasis, cell cycle regulation, and vesicle trafficking.
- Altered sorcin expression is implicated in non-neoplastic diseases like diabetes and nervous system disorders.
Purpose of the Study:
- To review the functions of sorcin.
- To explore the role of sorcin in non-neoplastic and neoplastic diseases.
- To discuss sorcin's relevance in drug resistance research.
Main Methods:
- Literature review of existing research on sorcin.
- Analysis of sorcin's expression patterns in various disease states.
- Examination of studies linking sorcin to multidrug resistance (MDR).
Main Results:
- Sorcin is widely distributed and involved in fundamental cellular processes.
- Sorcin expression is associated with non-neoplastic conditions.
- Sorcin overexpression is frequently observed in multidrug-resistant cancers.
Conclusions:
- Sorcin's involvement in cellular functions and disease pathogenesis is significant.
- Sorcin overexpression is strongly correlated with the development of multidrug resistance (MDR).
- Sorcin represents a promising novel target for overcoming MDR in cancer therapy.
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