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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
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CD4/CD8 Ratio as a Predictor for the Occurrence of Metabolic Syndrome in HIV / AIDS Patients During 6 Months of cART

Refet Gojak1, Vesna Hadžiosmanović1, Rusmir Baljić1

  • 1University Clinical Centre Sarajevo, Clinic for Infectious Diseases, Sarajevo, Bosnia and Herzegovina.

Journal of Medical Biochemistry
|September 10, 2019
PubMed

Insights

The CD4/CD8 ratio can predict metabolic syndrome (MetS) in HIV patients on cART. A lower ratio indicates a higher risk of developing MetS, offering a valuable prognostic marker.

Area of Science:

  • Immunology
  • Metabolic Health
  • HIV/AIDS Research

Background:

  • HIV infection causes CD4+ T cell depletion and CD8+ T cell expansion.
  • The CD4/CD8 ratio, a marker of immune aging, is increasingly relevant in HIV outcomes.
  • Metabolic syndrome (MetS) is a growing concern for HIV-positive individuals on combination antiretroviral therapy (cART).

Purpose of the Study:

  • To investigate the predictive power of the CD4/CD8 ratio for MetS development in HIV patients receiving cART.
  • To identify key immunological and clinical factors associated with MetS in this population.

Main Methods:

  • Retrospective case-control study of 80 HIV/AIDS patients.
  • Flow cytometry to determine CD4+ and CD8+ T cell percentages.
  • Evaluation of biochemical, immunological, and anthropometric parameters, alongside cART regimen.

Main Results:

  • MetS was diagnosed in 23.8% of subjects after six months of cART.
  • Multivariate analysis revealed the CD4/CD8 ratio as a significant predictor of MetS (p < 0.05, OR = 0.45).
  • cART and triglyceride levels also predicted MetS, while body weight and waist circumference did not show statistical significance.

Conclusions:

  • The CD4/CD8 ratio is a significant predictive marker for metabolic syndrome in HIV/AIDS patients.
  • This ratio offers valuable insights into MetS risk stratification in individuals undergoing cART.
Abstract

Keywords:
CD4/CD8 ratioHIV/AIDScARTmetabolic syndrome

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