Related Experiment Video
Updated: Jan 19, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
The survival analysis and oncogenic effects of CFP1 and 14-3-3 expression on gastric cancer
Jingyue Sun1,2,3,4, Yao Long1,2,3,5, Xin Peng1,2,3,4
11Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South University, Hunan, 410078 China.
Background & Aim:
Gastric cancer (GC) is the third-leading cause of cancer-related deaths. We established a prospective database of patients with GC who underwent surgical treatment. In this study, we explored the prognostic significance of the expression of CFP1 and 14-3-3 in gastric cancer, by studying the specimens collected from clinical subjects.
Materials & Methods:
Immunohistochemistry was used to detect the expression of CFP1 and 14-3-3 in 84 GC subjects, including 73 patients who have undergone radical gastrectomy and 11 patients who have not undergone radical surgery. Survival analysis was performed by km-plot data.
Results:
According to the survival analysis, we can see that the survival time of patients with high expression of CFP1 is lower than the patients with low expression in gastric cancer, while the effect of 14-3-3 is just the opposite. The survival time of patients with higher expression of 14-3-3 is also longer.
Conclusion:
The CFP1 and 14-3-3 genes can be used as prognostic markers in patients with GC, but the study is still needed to confirm.
More Related Videos
Related Concept Videos
06:24Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:44Bioluminescence Resonance Energy Transfer (BRET)-Based Assay for Measuring Interactions of CRAF with 14-3-3 Proteins in Live Cells
Cancer Survival Analysis
09:243-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
07:32Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
07:35Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 3

