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Updated: Jan 19, 2026
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
Published on: December 10, 2021
Modelling of atherosclerosis in genetically modified animals
Natalia V Mushenkova1, Volha I Summerhill2, Yulia Yu Silaeva3
1Pharmstandard Ventures 10 Testovskaya Street, Moscow 123112, Russia.
Insights
Animal models are crucial for studying atherosclerosis, a chronic inflammatory disease impacting cardiovascular health. This review discusses various genetic models in mice, rabbits, and pigs to advance research and treatment strategies.
Area of Science:
- Cardiovascular Science
- Immunology
- Pathology
Background:
- Atherosclerosis is a chronic inflammatory disease driven by lipids, causing arterial plaque formation and significant cardiovascular disease (CVD) morbidity and mortality.
- Animal models are essential for investigating atherosclerosis etiology, pathogenesis, complications, and for testing therapies and imaging techniques.
Purpose of the Study:
- To review and discuss the advantages and disadvantages of available murine, rabbit, and porcine genetic models for atherosclerosis research.
Main Methods:
- Review of existing literature on animal models of atherosclerosis.
- Discussion of genetic manipulation and diet-induced models.
- Comparative analysis of murine, rabbit, and porcine models.
Main Results:
- A variety of animal models exist, induced by atherogenic diets or genetic modifications.
- Specific genetic models in mice, rabbits, and pigs offer distinct advantages for studying atherosclerosis.
Conclusions:
- Genetic animal models provide valuable platforms for understanding atherosclerosis and evaluating potential treatments.
- Selection of appropriate models is critical for successful atherosclerosis research and therapeutic development.
Abstract:
Atherosclerosis is a lipid-driven, chronic inflammatory disease that leads to plaque formation at specific sites of the arterial tree. Being the common cause of many cardiovascular disorders, atherosclerosis makes a tremendous impact on morbidity and mortality rates of cardiovascular diseases (CVDs) in countries with higher income. Animal models of atherosclerosis are utilized as useful tools for studying the aetiology, pathogenesis and complications of atherosclerosis, thus, providing a valuable platform for the efficacy testing of different pharmacological therapies and validation of imaging techniques. To date, a large variety of models is available. Pathophysiological changes can be induced in animals by either an atherogenic diet or genetic manipulations. The discussion of advantages and disadvantages of some murine, rabbit and porcine genetic models currently available for the atherosclerosis research is the scope of the following review.
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