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Overexpression of B7-H3 as an opportunity for targeted therapy in head and neck cancers

Juanjuan Hu1, Caiying Jiang2, Meijun Zheng1

  • 1Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University Chengdu, Sichuan, P. R. China.

American Journal of Translational Research
|September 10, 2019
PubMed

Insights

B7-H3 is highly expressed in most head and neck cancers (HNCs), correlating with poor survival. Novel bispecific antibodies targeting B7-H3 show promise for treating HNCs by inhibiting tumor growth and improving survival.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Biology

Background:

  • Head and neck cancers (HNCs) represent a significant global health burden with poor prognoses despite current treatments.
  • B7-H3 is an immune checkpoint molecule whose role in HNCs requires further investigation as a potential therapeutic target.

Purpose of the Study:

  • To investigate the expression profile of B7-H3 in head and neck cancers.
  • To evaluate B7-H3 as a potential therapeutic target for HNCs using anti-B7-H3×CD3 bispecific antibodies (biAbs).

Main Methods:

  • Analysis of B7-H3 expression in 274 clinical HNC samples and correlation with clinicopathological parameters.
  • Construction and in vitro/in vivo assessment of anti-B7-H3×CD3 biAbs efficacy against HNC cell lines and xenograft models.

Main Results:

  • High B7-H3 expression was detected in 66.1% of HNC samples, significantly associated with poorer patient survival.
  • Anti-B7-H3×CD3 biAbs demonstrated specific antitumor effects in vitro and significantly delayed tumor growth and prolonged survival in vivo.

Conclusions:

  • B7-H3 is frequently overexpressed in head and neck cancers and serves as a viable therapeutic target.
  • Anti-B7-H3×CD3 bispecific antibody therapy shows potential as a novel treatment strategy for HNCs.
Keywords:
B7-H3bispecific antibodieshead and neck cancersimmunotherapy

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