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Updated: Jan 19, 2026
In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
Targeting snoRNAs as an emerging method of therapeutic development for cancer
Di Zhang1,2, Juan Zhou3, Jie Gao1,2
1Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, Guangxi Zhuang Autonomous Region, China.
Abstract:
The relevance of the dysregulation of snoRNAs in human cancer has been widely investigated and has challenged the view that snoRNAs merely function as house-keeping genes for the posttranscriptional modification of rRNAs. Accumulating evidence has shown the intimate connection between snoRNAs and proliferation, apoptosis, invasion and migration of tumor cells via manual intervention patterns of snoRNA expression. In this review, we focused on how snoRNAs are dysregulated and its regulation of the formation and development of cancer. We summarized the non-classical functions of snoRNAs in the context of their regulations of the signaling pathways involving PI3K-AKT and K-Ras and p53-dependant manner. Under these novel functions and characteristics, snoRNAs can act as potential and feasible biomarkers for diagnosis. Simultaneously, these promising therapeutic strategies should be considered to counteract the perturbations of snoRNAs.
Insights
Small nucleolar RNAs (snoRNAs) are increasingly linked to cancer development, influencing cell proliferation and apoptosis. Dysregulated snoRNAs offer potential as cancer biomarkers and therapeutic targets.
Area of Science:
- Molecular Biology
- Oncology
- Gene Regulation
Background:
- Small nucleolar RNAs (snoRNAs) were traditionally viewed as housekeeping genes.
- Emerging evidence highlights their significant role in human cancer.
- Dysregulation of snoRNAs impacts critical cellular processes like proliferation and apoptosis.
Purpose of the Study:
- To review the dysregulation of snoRNAs in cancer.
- To explore the non-classical functions of snoRNAs in cancer development.
- To discuss the potential of snoRNAs as diagnostic biomarkers and therapeutic targets.
Main Methods:
- Literature review of studies on snoRNA dysregulation in cancer.
- Analysis of snoRNA involvement in key signaling pathways (PI3K-AKT, K-Ras, p53).
- Evaluation of snoRNAs as biomarkers and therapeutic strategies.
Main Results:
- SnoRNAs are intimately connected with tumor cell proliferation, apoptosis, invasion, and migration.
- SnoRNAs regulate cancer formation and development through non-classical functions.
- SnoRNAs modulate signaling pathways including PI3K-AKT, K-Ras, and p53.
- Dysregulated snoRNA expression patterns are observed in various cancers.
Conclusions:
- SnoRNAs exhibit non-canonical functions beyond rRNA modification in cancer.
- SnoRNAs play crucial roles in regulating cancer cell behavior and signaling pathways.
- SnoRNAs represent promising biomarkers for cancer diagnosis.
- Targeting snoRNA perturbations offers a potential therapeutic strategy for cancer treatment.
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