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Related Experiment Video

Updated: Jan 19, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Sequential Targeted Temperature Management: Case Report and Literature Review.

Sebastian Casillas¹, Joseph Varon², Salim Surani³

¹Research, Dorrington Medical Associates, Houston, USA.

|September 10, 2019

Summary

Sequential targeted temperature management (TTM) is crucial for neuroprotection in patients experiencing repeat cardiac arrests. This case highlights TTM

Keywords:

cardiac arrest compromised airway hypothermia radiation chondronecrosis targeted temperature management

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Published on: November 8, 2024

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Last Updated: Jan 19, 2026

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Published on: November 21, 2017

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Area of Science:

Neurology
Cardiology
Critical Care Medicine

Background:

A 59-year-old male with tonsillar cancer and radiation chondronecrosis underwent therapeutic hypothermia.
The patient experienced respiratory and cardiac arrest post-laryngoscopy, necessitating initial targeted temperature management (TTM).

Observation:

Following rewarming, the patient developed upper airway obstruction and a second prolonged cardiac arrest.
Return of spontaneous circulation (ROSC) was achieved after 45 minutes of resuscitation.

Findings:

Sequential TTM was initiated again, with the patient cooled to 32°C for 48 hours.
The patient recovered with intact neurological function five days after the second cooling period.

Implications:

This case underscores the neuroprotective potential of sequential TTM following recurrent cardiac arrest and ROSC.
Sequential TTM may be a vital treatment strategy in critical care settings for preserving neurological function after severe ischemic events.