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[Azoles. 18. Sulfonylindazole derivatives]
J Dudzińska-Usarewicz1, U Wrzeciono, A Frankiewicz
1Lehrstuhl für Organische Chemie der Karol Marcinkowski Medizinischen Akademie, Poznań, VR Polen.
Die Pharmazie
|September 1, 1988
Abstract:
The nucleophilic substitution of hydrogen to synthesize the sulphonyl indazole derivatives 9-16 is described. The structures of the substitution products are discussed using H-NMR spectra. Chemical structural proof was given by steric hindrance observed in the process of chorination of 9-16. The compounds 3, 4, 7, 8, 14, and 16 are studied to find an inhibition on phospholipase-A2 and lipoxygenase-I.