ECG changes after percutaneous edge-to-edge mitral valve repair

Area of Science:

• Cardiology
• Cardiac Electrophysiology
• Medical Devices

Background:

• Mitral regurgitation (MR) severely impacts hemodynamics and causes left atrial remodeling, increasing the risk of atrial arrhythmias.
• Atrial remodeling alters electrical properties, potentially leading to atrial fibrillation and flutter.
• Percutaneous mitral valve repair (PMVR) is effective for MR in high-risk patients but its effect on electroanatomical changes is unknown.

Purpose of the Study:

• To investigate electrocardiogram (ECG) changes following PMVR in patients with MR.
• To assess the impact of MR reduction via PMVR on atrial electrical activity and conduction.

Main Methods:

• Evaluated 104 surface ECGs from patients in sinus rhythm before and after PMVR.
• Analyzed P wave duration, P wave amplitude, PR interval, QRS duration, QRS axis, and QT interval.

Main Results:

• Successful PMVR did not alter QRS duration, QRS axis, or QT interval.
• Significant reductions were observed in P wave duration, P wave amplitude, and PR interval post-PMVR (P < .05).

Conclusions:

• PMVR leads to significant improvements in atrial electrical conduction and properties.
• These findings provide insight into atrial electroanatomical changes after MR reduction with PMVR in sinus rhythm patients.