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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Rare Presentation of Postsurgical Pyoderma Gangrenosum Presenting as Necrotizing Soft Tissue Infection
Rod L Flynn1, Mashiul H Chowdhury, Joseph Rudolph
1Rod L. Flynn, MD, is Medical Director of Surgical Oncology, The Christ Hospital, Cincinnati, Ohio. At the Cancer Treatment Centers of America, in Philadelphia, Pennsylvania, Mashiul H. Chowdhury, MD, is Chief of Infectious Diseases; Joseph Rudolph, MSN, AGPCNP-BC, CWOCN, is a nurse practitioner, Department of Skin, Wound and Ostomy Care; and Stephanie Einstein, MSN, AGPCNP-BC, CWOCN, is a nurse practitioner, Department of Skin, Wound and Ostomy Care. The authors have disclosed no financial relationships related to this article. Submitted February 11, 2019; accepted in revised form April 17, 2019; published online ahead of print September 5, 2019.
Abstract:
Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis believed to be mediated by an autoimmune reaction. Typical treatment includes autolytic debridement, management of exudate, protection from trauma, and steroid therapy. A diagnosis of exclusion, PG is frequently mistaken for a wound infection, but antibiotics do not alleviate the condition. Incision and debridement has been observed to cause further spread of the lesions because of pathergy resulting from the additional trauma. This case report describes a patient who was misdiagnosed with necrotic soft tissue infection that was actually postsurgical PG.
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