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Related Experiment Video

Updated: Jan 19, 2026

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Systemic sclerosis.

Michael Hughes1, Ariane L Herrick2

  • 1Consultant Rheumatologist, Department of Rheumatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF.

British Journal of Hospital Medicine (London, England : 2005)
|September 10, 2019
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis is a complex autoimmune disease affecting multiple organs, often starting with vascular issues like Raynaud's phenomenon. Advances in understanding its pathogenesis are leading to better treatments for its diverse complications.

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic sclerosis is a severe autoimmune connective tissue disease with significant morbidity and potential life-threatening complications.
  • It affects multiple organs, requiring multidisciplinary specialist care.
  • Vascular disease, notably Raynaud's phenomenon, is a near-universal and often initial symptom.

Purpose of the Study:

  • To provide an updated overview for clinicians on systemic sclerosis.
  • To cover epidemiology, pathogenesis, differential diagnosis, clinical spectrum, and treatments.
  • To highlight recent advances in understanding and managing the disease.

Main Methods:

  • Literature review of systemic sclerosis.
  • Synthesis of current knowledge on pathogenesis and treatment.
  • Focus on clinical aspects relevant to specialists.

Main Results:

  • Major advances in understanding pathogenesis are driving treatment innovations.
  • Effective treatments exist for many organ-specific complications.
  • Autologous hematopoietic stem cell transplantation is a potential option for select patients.

Conclusions:

  • Systemic sclerosis management benefits from understanding its complex pathogenesis.
  • Current treatments effectively manage various organ manifestations.
  • Ongoing research promises further therapeutic advancements for this challenging disease.