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Related Concept Videos

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

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Here, we present a protocol for a mouse model of noise-induced hearing loss (NIHL). To induce NIHL, we developed a new and simple device using corrugated plastic, a rat trap cage, and a speaker. Auditory brainstem response and immunofluorescence imaging were employed to assess the hearing function and outer hair cell damage,...
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Inducing Hearing Loss in Mice Through Prolonged High-Volume Sound Exposure01:52

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Source: Lee, D. et. al., Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage. J. Vis. Exp. (2023)This video demonstrates the procedure of noise-induced hearing loss in mice. High-volume sound damages hair cells in the inner ear and disrupts auditory pathways, resulting in hearing...
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Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode03:49

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Electric acoustic stimulation (EAS) with longer electrodes can offer broader cochlear coverage and various types of maps in cases of high-frequency hearing loss. Combining less invasive surgery, flexible lateral-wall electrodes, and steroid administration permits deeper insertion with little or no surgical trauma, resulting in good preservation of...
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This article reports the development of a neuro-rehabilitation approach, "constraint-induced sound therapy (CIST)" for sudden sensorineural hearing loss. The aim of CIST is to prevent maladaptive cortical reorganization by using an enriched acoustic environment. CIST represents a safe, easy, inexpensive, and effective approach to treat sudden sensorineural hearing...
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Simple Surgical Induction of Conductive Hearing Loss with Verification Using Otoscope Visualization and Behavioral Clap Startle Response in Rat06:27

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Hearing

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When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
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Related Experiment Video

Updated: Jan 19, 2026

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

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What is noise-induced hearing loss?

Tonghui Ding1, Aihui Yan2, Ke Liu3

  • 1Resident Doctor, Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, China.

British Journal of Hospital Medicine (London, England : 2005)
|September 10, 2019
PubMed
Summary

Long-term exposure to noise causes permanent hearing loss and tinnitus, impacting quality of life. Current treatments are ineffective, highlighting the need for further research and public hearing health education.

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Area of Science:

  • Otorhinolaryngology
  • Environmental Health

Background:

  • Noise-induced hearing loss (NIHL) is a growing concern due to increased societal noise exposure.
  • Auditory fatigue is an early indicator, but prolonged noise exposure leads to irreversible damage.
  • NIHL and associated tinnitus significantly reduce quality of life and incur substantial economic costs.

Purpose of the Study:

  • To review the complex pathogenesis of noise-induced hearing loss.
  • To highlight the limitations of current understanding and treatment options for NIHL.
  • To emphasize the importance of preventative strategies and public education.

Main Methods:

  • Literature review on noise-induced hearing loss.
  • Analysis of existing theories on NIHL pathogenesis, including oxidative stress.
  • Examination of current treatment efficacy and preventative measures.

Main Results:

  • The pathogenesis of NIHL is complex and not fully explained by current theories like oxidative stress.
  • Existing treatments cannot completely reverse noise-induced auditory damage.
  • Societal trends increase the risk of noise exposure and subsequent hearing impairment.

Conclusions:

  • Further research is crucial to elucidate NIHL pathogenesis for improved clinical guidance.
  • Effective treatments for reversing NIHL damage are currently unavailable.
  • Public health initiatives focusing on hearing protection and education are essential to mitigate NIHL prevalence.