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Updated: Jan 19, 2026

Author Spotlight: Advancing Structural and Biochemical Studies of Proteins Through Thermal Shift Assays
Published on: August 9, 2024
Imidazo[1,5-α]pyridine-based fluorescent probe with a large Stokes shift for specific recognition of sulfite
Song Chen1, Peng Hou2, Jingwen Sun2
1College of Pharmacy, Qiqihar Medical University, 333 Bukui Street, Qiqihar, Heilongjiang Province 161006, PR China,.
Abstract:
By taking advantage of the intramolecular charge transfer (ICT) process, we presented a novel fluorescent probe IPY-SO2 based on imidazo[1,5-α]pyridine derivative for detecting SO32- with a low detection limit (70 nM). Combining its favorable turn-on fluorescence feature (75-fold), rapid response (5 min), high selectivity, large Stokes shift (174 nm) and low cytotoxicity, IPY-SO2 was successfully applied to imaging SO32 in living MCF-7 cells and zebrafish.
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