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Updated: Jan 19, 2026
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Published on: December 3, 2025
Minimal constraints for maximum caliber analysis of dissipative steady-state systems
Luca Agozzino1,2, Ken Dill1,2,3
1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794, USA.
Abstract:
Maximum caliber (Max Cal) is purported to be a general variational principle for nonequilibrium statistical physics. But recently, Jack and Evans [J. Stat. Mech.: Theory Exp. (2016) 0933051742-546810.1088/1742-5468/2016/09/093305] and Maes [Non-Dissipative Effects in Nonequilibrium Systems (Springer, New York, 2018)] have raised concerns about how Max Cal handles dissipative processes. Here, we show that the problem does not lie in Max Cal; the problem is in the use of insufficient constraints. We also present an exactly solvable single-particle model of dissipation, valid far from equilibrium, and its solution by maximum caliber. The model illustrates how the influx and efflux of work and heat into a flowing system alters the distribution of trajectories. Maximum caliber is a viable principle for dissipative systems.
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