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Updated: Jan 19, 2026

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
Published on: December 13, 2010
Fabrication of collagen membranes with different intrafibrillar mineralization degree as a potential use for GBR
Jing Wang1, Yinan Qu1, Chaoqun Chen1
1Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, PR China.
Abstract:
The process of biomineralization in dentin and bone tissue repair has been extensively studied. In vitro, biomineralization can be stimulated via a polymer-induced liquid precursor (PILP) process. Guided bone regeneration using a barrier membrane and bone substitute materials is widely used in implantology in cases where there is insufficient bone volume. Herein, we applied a homologous PILP processes to fabricate collagen films with a varying degree of mineralization and tested their performance. The results showed that the prepared biomineralized membranes are biocompatible, have a high stress strength and can promote MC3T3-e1 cell proliferation. This indicated that the membranes can be potentially applied in guided bone regeneration, with membranes containing a higher degree of mineralization achieving the best results.
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