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Updated: Jan 19, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Editorial Commentary: Revising a Failed Osteochondral Allograft-Further Down the Rabbit Hole We Go…
1La Jolla, California.
Abstract:
Fresh osteochondral allografting has gained popularity as a useful technique for managing difficult cartilage repair problems and, in revision situations, is a treatment of choice when other procedures such as microfracture, osteochondral autograft transfer, and cell-based therapies fail. However, it is a challenge when an allograft fails. Absent substantial progression of osteoarthritis, revising with another allograft results in a reasonable chance of "success" (but a high likelihood of further surgery along the way). Thus, in the setting of a failed osteochondral allograft, sometimes the best option is to keep going further down the rabbit hole and revise a failed allograft with an allograft.
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