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Related Experiment Video

Updated: Jan 19, 2026

Necrosis
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Secondary colonic necrosis. Case report.

Ma Del Carmen Aburto-Fernández1, Adán Araujo-López1, Irwin U García-Godoy1

  • 1Servicio de Cirugía General, Hospital General de Querétaro, Querétaro, México.

Cirugia Y Cirujanos
|September 11, 2019
PubMed
Summary

Verapamil overdose can cause colonic vascular lesions and necrosis, leading to acute abdomen. Prompt surgical intervention is crucial for survival, though diagnosis can be challenging.

Keywords:
Abdomen agudoAcute abdomenColonic vascularityVascularidad colónicaVerapamilVerapamilo

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Area of Science:

  • Gastroenterology
  • Toxicology
  • Emergency Medicine

Background:

  • Colonic vascular lesions from verapamil overdose involve free radical damage, microthrombosis, and endotoxin generation.
  • This condition presents diagnostic challenges in acute abdominal cases.

Observation:

  • A 27-year-old female presented with acute abdomen following a verapamil overdose suicide attempt.
  • Surgical exploration revealed right transmural colon necrosis.

Findings:

  • The patient underwent a right hemicolectomy with terminal ileostomy due to extensive colon necrosis.
  • This case highlights the severe gastrointestinal complications of verapamil toxicity.

Implications:

  • Accurate diagnosis of acute abdomen requires a thorough patient history, especially in overdose cases.
  • Early recognition and surgical management are vital for patients with verapamil-induced colonic necrosis.