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Related Experiment Video

Updated: Jan 19, 2026

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
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Lipid nanostructures for antioxidant delivery: a comparative preformulation study.

Elisabetta Esposito1, Maddalena Sguizzato1, Markus Drechsler2

  • 1Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.

Beilstein Journal of Nanotechnology
|September 11, 2019
PubMed
Summary

New lipid nanoparticles deliver antioxidants to protect skin from aging caused by pollutants like cigarette smoke. Tristearin-based nanostructured lipid carriers loaded with alpha-tocopherol showed significant protective effects in human skin explants.

Keywords:
HO-1cryogenic transmission electron microscopy (cryo-TEM)dermocosmeticsnanostructured lipid carriers (NLCs)retinoic acidskin pollutionsolid lipid nanoparticles (SLNs)α-tocopherol

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Area of Science:

  • Cosmetic Science
  • Materials Science
  • Dermatology

Background:

  • Antioxidants like alpha-tocopherol and retinoic acid can improve skin condition and mitigate aging effects from environmental stressors.
  • Developing effective delivery systems is crucial for enhancing antioxidant efficacy in skin protection.

Purpose of the Study:

  • To design and develop novel lipid nanoparticles for cutaneous delivery of antioxidant agents.
  • To evaluate the potential of these nanoparticles in protecting human skin against pollutants, specifically cigarette smoke.

Main Methods:

  • Preparation and characterization of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) using various lipids.
  • Physico-chemical characterization including particle size, morphology (cryo-TEM), structure (SAXRD), encapsulation efficiency, and stability.
  • In vitro cytotoxicity and ex vivo assessment of protective effects against cigarette smoke exposure on human skin explants.

Main Results:

  • NLCs demonstrated improved dimensional stability and reduced agglomeration compared to SLNs, indicating suitability for antioxidant loading.
  • Tristearin-based NLCs loaded with alpha-tocopherol exhibited superior physico-chemical properties.
  • Ex vivo studies showed that alpha-tocopherol-loaded NLC pretreatment significantly reduced the upregulation of heme oxygenase, a stress-induced enzyme, in skin explants exposed to cigarette smoke.

Conclusions:

  • Nanostructured lipid carriers are promising platforms for delivering antioxidants to the skin.
  • Tristearin-based NLCs loaded with alpha-tocopherol offer significant protection against cigarette smoke-induced skin damage.
  • These findings suggest a potential therapeutic application for lipid nanoparticles in preventing skin aging and damage from environmental pollutants.