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ABCD: Alzheimer's disease Biomarkers Comprehensive Database.

Ashwani Kumar1, Ankush Bansal1, Tiratha Raj Singh1

  • 1Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh 173234 India.

3 Biotech
|September 11, 2019
PubMed
Summary

Alzheimer's disease (AD) is a progressive brain disorder lacking effective biomarkers. The Alzheimer's disease Biomarkers Comprehensive Database (ABCD) consolidates molecular markers, pathways, and imaging data to aid AD research.

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Area of Science:

  • Neuroscience
  • Genetics
  • Bioinformatics

Background:

  • Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disorder characterized by memory loss and cognitive decline.
  • The absence of effective biomarkers hinders the development of comprehensive AD treatments.
  • A centralized resource for AD-related data is crucial for the scientific community.

Purpose of the Study:

  • To establish the Alzheimer's disease Biomarkers Comprehensive Database (ABCD) as a dedicated resource for AD research.
  • To consolidate diverse AD-related data, including molecular markers, pathways, and patient imaging data.
  • To facilitate data extraction, analysis, and visualization for researchers studying Alzheimer's disease.

Main Methods:

  • Developed a web interface to host a comprehensive collection of AD-related molecular marker data.
Keywords:
Alzheimer’s diseaseDatabaseDementiaGene expressionPathways

Related Experiment Videos

  • Integrated information on proteins, genes, transcription factors, SNPs, miRNAs, mitochondrial and expressed genes implicated in AD.
  • Included data on animal models, medicinal candidates, pathways, and neuroimaging data from AD patients.

    • Main Results:

    • The ABCD database provides extensive molecular-level data relevant to AD pathogenesis.
    • The resource incorporates information on animal models, drug candidates, and biological pathways associated with AD.
    • Advanced features include search functionalities for genes, proteins, and pathways, alongside AD patient brain image data.

    Conclusions:

    • The ABCD database serves as a unique, specialized resource for Alzheimer's disease research.
    • Its comprehensive data and advanced features empower researchers to extract and analyze AD-related information effectively.
    • The database aims to advance understanding and facilitate the development of potential therapeutic strategies for Alzheimer's disease.