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[Pathogenesis of hand eczema].

Sonja Molin1

  • 1Division of Dermatology, Queen's University, 166 Brock Street, ON K7L 5G2, Kingston, Kanada. s.molin@queensu.ca.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|September 11, 2019
PubMed
Summary

Hand eczema results from multiple factors, including skin barrier impairment and genetic predisposition beyond atopy. Understanding individual causes is key for effective treatment and allergen avoidance.

Keywords:
AtopyContact sensitizationEpidermal skin protection barrierImmunological processesIrritative contact dermatitis

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Hand eczema pathogenesis is multifactorial, involving exogenous irritants, contact sensitization, and endogenous atopic predisposition.
  • Skin barrier dysfunction is a critical factor in hand eczema development.

Purpose of the Study:

  • To review the pathogenetic factors contributing to the development of hand eczema.
  • To explore the interplay of genetic, immunological, and environmental influences.

Main Methods:

  • Comprehensive literature review on hand eczema pathogenesis.
  • Evaluation of current research on etiological factors.

Main Results:

  • Epidermal barrier impairment is central to hand eczema.
  • Genetic predisposition beyond atopy and its molecular basis require further investigation.
  • Immunological pathways in allergic contact dermatitis and atopic eczema are implicated in specific hand eczema subtypes.

Conclusions:

  • Individualized understanding of hand eczema pathogenesis is crucial for targeted interventions.
  • Specific advice on allergen avoidance, skin protection, and treatment initiation relies on precise etiological diagnosis.