Related Experiment Video
Updated: Jan 19, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
Published on: September 16, 2022
Focused size selection of cell-free DNA samples for liquid biopsy applications that rely on next-generation
1Ripple Biosolutions LLC, 2626 NE 86th Street, Seattle, WA 98115, USA.
Abstract:
Genomic analysis of circulating, cell-free DNA (cfDNA) is being used extensively for molecular diagnostics. Many approaches rely on the construction of cfDNA genomic libraries, targeted retrieval of specific genomic regions and analysis by next-generation DNA sequencing. Several steps during sample preparation require isolation of DNA fragments within a particular size range. In this Benchmark article, two related methods for size-selective DNA fragment enrichment are described.
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