Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

8.3K
Crystallization-driven self-assembly (CDSA) displays the unique ability to fabricate cylindrical nanostructures of narrow length distributions. The organocatalyzed ring-opening polymerization of ε-caprolactone and subsequent chain extensions of methyl methacrylate and N,N-dimethyl acrylamide are demonstrated. A living CDSA protocol that produces monodisperse cylinders up to 500 nm in length is...
8.3K
Protein Complex Assembly02:41

Protein Complex Assembly

16.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.6K
Protein Complex Assembly02:41

Protein Complex Assembly

2.5K
2.5K
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

14.6K
The key steps of living anionic polymerization of phenyl glycidyl ether (PheGE) on methoxy-polyethylene glycol (mPEG-b-PPheGE) are described. The resulting block copolymer micelles (BCMs) were loaded with doxorubicin 14% (wt%) and sustained release of drug over 4 days under physiologically relevant conditions was...
14.6K
Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

9.5K
A method for the functionalization of carbon nanotubes with structure-tunable polymeric encapsulation layers and structural characterization using small-angle neutron scattering is...
9.5K
Protein and Protein Structure02:15

Protein and Protein Structure

86.9K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
86.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutinase Adsorption to Polyester Surfaces Modulates Dissolved Oligomer Speciation during Enzymatic Depolymerization.

Biomacromolecules·2026
Same author

Identification of circCIAO1(5) and circMALAT1 as Novel Potential Biomarkers for Bladder Cancer Monitoring Based on the Binding to miR-101-3p.

Cancers·2026
Same author

Training the Military Surgical Resident for Tomorrow's War: A Military-Unique Curriculum at the Uniformed Services University and Walter Reed National Military Medical Center.

Military medicine·2026
Same author

A Canonical Text Representation for Polymers via BigSMILES and Tree Automata.

Journal of chemical information and modeling·2026
Same author

Natural language processing models for patient-centered summaries of prostatectomy pathology reports.

Scientific reports·2026
Same author

Dynamics of synthetic transcriptional condensates emerge from RNA synthesis and degradation.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 19, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.3K

Predicting Protein-Polymer Block Copolymer Self-Assembly from Protein Properties.

Aaron Huang1, Justin M Paloni1, Amy Wang1

  • 1Department of Chemical Engineering , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.

Biomacromolecules
|September 11, 2019
PubMed
Summary

Protein-polymer bioconjugates self-assemble into ordered structures. Their phase behavior, particularly hexagonal phases, depends on protein molecular weight and beta sheet content, enabling predictable design.

More Related Videos

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

14.6K
Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

9.5K

Related Experiment Videos

Last Updated: Jan 19, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.3K
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

14.6K
Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

9.5K

Area of Science:

  • Materials Science
  • Biotechnology
  • Polymer Chemistry

Background:

  • Protein-polymer bioconjugates are investigated for fabricating nanomaterials.
  • Understanding self-assembly behavior is crucial for material design.

Purpose of the Study:

  • To identify protein properties influencing phase behavior in protein-PNIPAM block copolymers.
  • To develop a predictive model for bioconjugate self-assembly.

Main Methods:

  • Compiled and analyzed a library of 15 protein-PNIPAM copolymers with 11 different proteins.
  • Investigated phase behavior, including micellar, lamellar, and hexagonal phases.
  • Correlated phase behavior with protein properties like molecular weight and beta sheet content.

Main Results:

  • Observed common phase behaviors (micellar, lamellar, disordering) across bioconjugates.
  • Identified hexagonal phases specific to proteins in the 20-36 kDa range.
  • Found that protein molecular weight and beta sheet percentage accurately predict bioconjugate ordering.

Conclusions:

  • Protein molecular weight and beta sheet content are key predictors of self-assembly.
  • A predictive model for protein-PNIPAM bioconjugates is established.
  • The findings offer a framework for designing novel bioconjugate materials.