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Related Concept Videos

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

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Here, we present optimized tissue-clearing protocols to image the murine aorta in three dimensions (3D). We delineate state-of-the-art procedures for immunostaining, optical clearing, and imaging with the intent to define the anatomical proximity of the peripheral nervous system with atherosclerotic plaques and the adventitia in...
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In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis09:43

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We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy...
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis08:01

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This paper presents a method involving the synthesis and characterization of monocyte-targeting peptide amphiphile micelles and the corresponding assays to test for biocompatibility and ability of the micelle to bind to monocytes.
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Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

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The goal of this article is to describe how cardiac magnetic resonance can be used for the evaluation and diagnosis of a suspected cardiac thrombus. The method presented will describe data acquisition as well as the pre-procedure and post-procedure...
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Murine models of atherosclerosis are useful tools to investigate pathogenic pathways on a molecular level, but require standardized quantification of lesion development. This protocol describes an optimized method to determine lesion size in the major arterial vessels including the aortic root, aortic arch, and brachiocephalic...
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Point of care ultrasound (POCUS) is increasingly being utilized in airway management. Presented here are some clinical utilities of POCUS, including differentiating endotracheal and esophageal intubation, identification of the cricothyroid membrane in the event a surgical airway is required, and measuring anterior neck soft tissue to predict difficult airway management.
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Related Experiment Video

Updated: Jan 19, 2026

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

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Emerging techniques in atherosclerosis imaging.

Maaz Bj Syed1, Alexander J Fletcher1, Rachael O Forsythe1

  • 1British Heart Foundation Centre of Cardiovascular Science.

The British Journal of Radiology
|September 11, 2019
PubMed
Summary
This summary is machine-generated.

Advanced imaging techniques offer new ways to understand atherosclerosis, a major global health issue. By looking beyond basic morphology, these methods reveal plaque composition and metabolic activity, improving cardiovascular risk prediction.

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In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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Related Experiment Videos

Last Updated: Jan 19, 2026

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In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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Area of Science:

  • Cardiovascular Imaging
  • Immunomodulated Diseases
  • Vascular Biology

Background:

  • Atherosclerosis is a widespread, chronic inflammatory disease impacting numerous vascular beds globally.
  • Current imaging primarily assesses morphological features like stenosis, limiting comprehensive risk assessment.
  • Advances in CT, MR, and PET imaging enhance speed and resolution, expanding clinical utility.

Purpose of the Study:

  • To review current imaging techniques for atherosclerosis.
  • To explore how multimodality imaging enhances the depiction of plaque morphology and composition.
  • To highlight the potential of novel tracers and contrast agents for assessing plaque metabolic state.

Main Methods:

  • Review of modern imaging modalities including CT, MR, and PET.
  • Discussion of multimodality imaging approaches.
  • Integration of novel biological tracers and "smart" contrast agents.

Main Results:

  • Modern scanners offer improved speed and spatial resolution for cardiovascular imaging.
  • Multimodality imaging provides insights into vessel wall constituency and metabolic processes.
  • Novel agents can target specific disease processes and reveal plaque metabolic state.

Conclusions:

  • Advanced imaging modalities significantly improve the depiction of atherosclerotic plaque morphology.
  • Multimodality imaging and novel tracers enhance cardiovascular risk prediction by detailing plaque characteristics.
  • Future applications hold potential for precise clinical assessment of atherosclerotic disease activity.