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Related Concept Videos

Lymph Node Exam08:06

Lymph Node Exam

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Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA
The lymphatic system has two main functions: to return extracellular fluid back to the venous circulation and to expose antigenic substances to the immune system. As the collected fluid passes through lymphatic channels on its way back to the systemic circulation, it encounters multiple nodes consisting of highly concentrated clusters of...
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This protocol describes the identification and resection of sentinel lymph nodes to make the operation as easy and minimally invasive as...
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A technique for performing intravital microscopy of the inguinal lymph node (LN) is outlined. Such technique allows for real-time, in vivo study of the lymph node microvasculature and structure both during homeostasis and infection. This technique can be adapted to cell trafficking studies and to other lymph node...
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Related Experiment Video

Updated: Jan 19, 2026

Lymph Nodes: Head &amp; Neck, Axillae, Upper &amp; Lower Extremities
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Salvage pelvic lymph node dissection for lymph node recurrent prostate cancer.

Giuseppe Rosiello1, Marco Bandini, Alberto Briganti

  • 1Department of Urology and Division of Experimental Oncology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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Salvage pelvic lymph node dissection (SLND) offers a treatment option for recurrent prostate cancer (PCa) patients with lymph node-only disease. Careful patient selection and robotic approaches may improve outcomes, though further research is needed.

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Area of Science:

  • Urology
  • Oncology
  • Surgical Innovation

Background:

  • Prostate cancer (PCa) recurrence after radical prostatectomy often involves lymph node metastasis.
  • Salvage pelvic lymph node dissection (SLND) is being explored for patients with lymph node-only recurrence detected by advanced imaging.

Purpose of the Study:

  • To review the current role and outcomes of salvage pelvic lymph node dissection (SLND) in managing recurrent prostate cancer.
  • To evaluate the impact of patient selection, imaging, and surgical approach on SLND effectiveness.

Main Methods:

  • Review of current literature on salvage pelvic lymph node dissection for recurrent prostate cancer.
  • Analysis of oncological outcomes, including biochemical progression-free survival and overall survival.
  • Comparison of open versus robotic-assisted SLND approaches.

Main Results:

  • SLND shows encouraging oncological outcomes for selected patients, with 2-year biochemical progression-free survival of 23-64% and 5-year overall survival of 84%.
  • Accurate patient selection based on imaging and clinical factors is crucial for optimal outcomes.
  • Robotic SLND offers comparable oncological results with reduced perioperative complications versus open surgery.

Conclusions:

  • Salvage pelvic lymph node dissection is a viable option for carefully selected patients with lymph node-only recurrent prostate cancer.
  • Advancements in imaging and robotic techniques are expected to further enhance SLND outcomes.
  • Randomized controlled trials are necessary to definitively establish the efficacy and utility of SLND.